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Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Actively steering the chondrogenic differentiation of mesenchymal stromal cells (MSCs) into either permanent cartilage or hypertrophic cartilage destined to be replaced by bone has not yet been possible. During limb development, the developing long bone is exposed to a concentration gradient of oxyg...

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Detalhes bibliográficos
Main Authors: Leijten, Jeroen, Georgi, Nicole, Moreira Teixeira, Liliana, van Blitterswijk, Clemens A., Post, Janine N., Karperien, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183286/
https://ncbi.nlm.nih.gov/pubmed/25205812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410977111
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