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Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Actively steering the chondrogenic differentiation of mesenchymal stromal cells (MSCs) into either permanent cartilage or hypertrophic cartilage destined to be replaced by bone has not yet been possible. During limb development, the developing long bone is exposed to a concentration gradient of oxyg...

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Autors principals: Leijten, Jeroen, Georgi, Nicole, Moreira Teixeira, Liliana, van Blitterswijk, Clemens A., Post, Janine N., Karperien, Marcel
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183286/
https://ncbi.nlm.nih.gov/pubmed/25205812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410977111
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