Hypoxia Inhibits Hypertrophic Differentiation and Endochondral Ossification in Explanted Tibiae

PURPOSE: Hypertrophic differentiation of growth plate chondrocytes induces angiogenesis which alleviates hypoxia normally present in cartilage. In the current study, we aim to determine whether alleviation of hypoxia is merely a downstream effect of hypertrophic differentiation as previously describ...

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Main Authors: Leijten, Jeroen C. H., Moreira Teixeira, Liliana S., Landman, Ellie B. M., van Blitterswijk, Clemens A., Karperien, Marcel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503827/
https://ncbi.nlm.nih.gov/pubmed/23185479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049896
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