In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB(1) receptor antagonist radioligand [(125)I]SD7015 in CB(1) knock-out and wildtype mouse

We aimed to evaluate the novel high-affinity and relatively lipophilic CB(1) receptor (CB(1)R) antagonist radioligand [(125)I]SD7015 for SPECT imaging of CB(1)Rs in vivo using the multiplexed multipinhole dedicated small animal SPECT/CT system, NanoSPECT/CT(PLUS) (Mediso, Budapest, Hungary), in knoc...

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Bibliographic Details
Main Authors: Máthé, Domokos, Horváth, Ildikó, Szigeti, Krisztián, Donohue, Sean R., Pike, Victor W., Jia, Zisheng, Ledent, Catherine, Palkovits, Miklós, Freund, Tamás F., Halldin, Christer, Gulyás, Balázs
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182908/
https://ncbi.nlm.nih.gov/pubmed/23318272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2013.01.001
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