The decrease of dopamine D(2)/D(3) receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB(1) cannabinoid receptors in Parkinson’s disease: A preliminary autoradiographic study with the selective dopamine D(2)/D(3) antagonist [(3)H]raclopride and the novel CB(1) inverse agonist [(125)I]SD7015

Cannabinoid type-1 receptors (CB(1)Rs) modulate synaptic neurotransmission by participating in retrograde signaling in the adult brain. Increasing evidence suggests that cannabinoids through CB(1)Rs play an important role in the regulation of motor activities in the striatum. In the present study, w...

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Main Authors: Farkas, Szabolcs, Nagy, Katalin, Jia, Zhisheng, Harkany, Tibor, Palkovits, Miklés, Donohou, Sean R., Pike, Victor W., Halldin, Christer, Máthé, Domokos, Csiba, Laszló, Gulyás, Balázs
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180092/
https://ncbi.nlm.nih.gov/pubmed/22421165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2012.02.012
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