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The Polyphenols (−)-Epigallocatechin-3-Gallate and Luteolin Synergistically Inhibit TGF-β-Induced Myofibroblast Phenotypes through RhoA and ERK Inhibition

The presence of reactive stroma, predominantly composed of myofibroblasts, is directly associated with and drives prostate cancer progression. We have previously shown that (−)-Epigallocatechin-3-gallate (EGCG), in the form of Polyphenon E, significantly decreases serum levels of HGF and VEGF in pro...

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Autori principali: Gray, Alana L., Stephens, Charles A., Bigelow, Rebecca L. H., Coleman, David T., Cardelli, James A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182889/
https://ncbi.nlm.nih.gov/pubmed/25272043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109208
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