The Polyphenols (−)-Epigallocatechin-3-Gallate and Luteolin Synergistically Inhibit TGF-β-Induced Myofibroblast Phenotypes through RhoA and ERK Inhibition

The presence of reactive stroma, predominantly composed of myofibroblasts, is directly associated with and drives prostate cancer progression. We have previously shown that (−)-Epigallocatechin-3-gallate (EGCG), in the form of Polyphenon E, significantly decreases serum levels of HGF and VEGF in pro...

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Autors principals: Gray, Alana L., Stephens, Charles A., Bigelow, Rebecca L. H., Coleman, David T., Cardelli, James A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182889/
https://ncbi.nlm.nih.gov/pubmed/25272043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109208
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