Radiotherapy as an immunological booster in patients with metastatic melanoma or renal cell carcinoma treated with high-dose Interleukin-2: evaluation of biomarkers of immunologic and therapeutic response

BACKGROUND: Tumor cells killed by radiation therapy (RT) are a potentially good source of antigens for dendritic cell (DC) uptake and presentation to T-cells. RT upregulates cell death receptors such as Fas/CD95 and MHC-I, induces the expression of co-stimulatory molecules on tumor cells, and promot...

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Detalhes bibliográficos
Main Authors: Ridolfi, Laura, de Rosa, Francesco, Ridolfi, Ruggero, Gentili, Giorgia, Valmorri, Linda, Scarpi, Emanuela, Parisi, Elisabetta, Romeo, Antonino, Guidoboni, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182814/
https://ncbi.nlm.nih.gov/pubmed/25245327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0262-6
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