Low-dose temozolomide before dendritic-cell vaccination reduces (specifically) CD4(+)CD25(++)Foxp3(+) regulatory T-cells in advanced melanoma patients

BACKGROUND: In cancer immunotherapy, dendritic cells (DCs) play a fundamental role in the dialog between innate and adaptive immune response, but several immunosuppressive mechanisms remain to be overcome. For example, a high number of CD4(+)CD25(++)Foxp3(+) regulatory T-cells (Foxp3+Tregs) have bee...

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Detalhes bibliográficos
Main Authors: Ridolfi, Laura, Petrini, Massimiliano, Granato, Anna Maria, Gentilcore, Giusy, Simeone, Ester, Ascierto, Paolo Antonio, Pancisi, Elena, Ancarani, Valentina, Fiammenghi, Laura, Guidoboni, Massimo, de Rosa, Francesco, Valmorri, Linda, Scarpi, Emanuela, Nicoletti, Stefania Vittoria Luisa, Baravelli, Stefano, Riccobon, Angela, Ridolfi, Ruggero
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698134/
https://ncbi.nlm.nih.gov/pubmed/23725550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-135
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