Adjuvant Potential of Selegiline in Attenuating Organ Dysfunction in Septic Rats with Peritonitis

Selegiline, an anti-Parkinson drug, has antioxidant and anti-apoptotic effects. To explore the effect of selegiline on sepsis, we used a clinically relevant animal model of polymicrobial sepsis. Cecal ligation and puncture (CLP) or sham operation was performed in male rats under anesthesia. Three ho...

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Bibliographic Details
Main Authors: Tsao, Cheng-Ming, Jhang, Jhih-Gang, Chen, Shiu-Jen, Ka, Shuk-Man, Wu, Tao-Cheng, Liaw, Wen-Jinn, Huang, Hsieh-Chou, Wu, Chin-Chen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182482/
https://ncbi.nlm.nih.gov/pubmed/25268350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108455
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