Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4 and PD-L1 in mice with brain tumors

PURPOSE: Glioblastoma (GBM) is the most common form of malignant glioma in adults. Although protected by both the blood brain- and blood tumor-barriers, T cells actively infiltrate GBM. Previous work has shown that IDO, CTLA-4 and PD-L1 are dominant molecular participants in the suppression of GBM i...

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Библиографические подробности
Главные авторы: Wainwright, Derek A., Chang, Alan L., Dey, Mahua, Balyasnikova, Irina V., Kim, Chung Kwon, Tobias, Alex, Cheng, Yu, Kim, Julius W., Qiao, Jian, Zhang, Lingjiao, Han, Yu, Lesniak, Maciej S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182350/
https://ncbi.nlm.nih.gov/pubmed/24691018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0514
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