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Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs
1. Human clearance prediction for small- and macro-molecule drugs was evaluated and compared using various scaling methods and statistical analysis. 2. Human clearance is generally well predicted using single or multiple species simple allometry for macro- and small-molecule drugs excreted renally....
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4181675/ https://ncbi.nlm.nih.gov/pubmed/21892879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2011.598582 |
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