Prediction of Kidney Drug Clearance: A Comparison of Tubular Secretory Clearance and Glomerular Filtration Rate

BACKGROUND: Although proximal tubular secretion is the primary mechanism of kidney drug elimination, current kidney drug dosing strategies are on the basis of eGFR. METHODS: In a dedicated pharmacokinetic study to compare GFR with tubular secretory clearance for predicting kidney drug elimination, w...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Chen, Yan, Zelnick, Leila R., Hoofnagle, Andrew N., Yeung, Catherine K., Shireman, Laura M., Phillips, Brian, Brauchla, Calder C., de Boer, Ian, Manahan, Linda, Heckbert, Susan R., Himmelfarb, Jonathan, Kestenbaum, Bryan R.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2021
Subjects:
Clinical Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054886/
https://ncbi.nlm.nih.gov/pubmed/33239392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020060833
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