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Molecular Mechanism of MART-1(+)/A*0201(+) Human Melanoma Resistance to Specific CTL-Killing Despite Functional Tumor-CTL Interaction
Durable responses in metastatic melanoma patients remain generally difficult to achieve. Adoptive cell therapy with ex vivo engineered lymphocytes expressing high affinity T cell receptors TCRα/β for the melanoma antigen MART-1(27-35)/HLA A*0201 (recognized by F5 cytotoxic T lymphocytes [F5 CTLs]) h...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4180868/ https://ncbi.nlm.nih.gov/pubmed/21159666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1296 |
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