The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-κB/Snail/RKIP/PTEN Circuit

Melanoma is a highly metastatic cancer, and there are no current therapeutic modalities to treat this deadly malignant disease once it has metastasized. Melanoma cancers exhibit B-RAF mutations in up to 70% of cases. B-RAF mutations are responsible, in large part, for the constitutive hyperactivatio...

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Detalhes bibliográficos
Main Authors: Lin, Kimberly, Baritaki, Stavroula, Militello, Loredana, Malaponte, Graziella, Bevelacqua, Ylenia, Bonavida, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2010
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933925/
https://ncbi.nlm.nih.gov/pubmed/20827424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910373795
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