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The effect of multistage nanovector targeting of VEGFR2 positive tumor endothelia on cell adhesion and local payload accumulation

Nanovectors are a viable solution to the formulation of poorly soluble anticancer drugs. Their bioaccumulation in the tumor parenchyma is mainly achieved exploiting the enhanced permeability and retention (EPR) effect of the leaky neovasculature. In this paper we demonstrate that multistage nanovect...

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Detalhes bibliográficos
Main Authors: Martinez, Jonathan O., Evangelopoulos, Michael, Karun, Vivek, Shegog, Evan, Wang, Joshua A., Boada, Christian, Liu, Xuewu, Ferrari, Mauro, Tasciotti, Ennio
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180774/
https://ncbi.nlm.nih.gov/pubmed/25176066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.08.024
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