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Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro

Thyroid hormone (TH) modulates serum cholesterol by acting on TH receptor β1 (TRβ1) in liver to regulate metabolic gene sets. In rodents, one important TH regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and play...

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Bibliografiske detaljer
Main Authors: Lammel Lindemann, Jan A., Angajala, Anusha, Engler, David A., Webb, Paul, Ayers, Stephen D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180720/
https://ncbi.nlm.nih.gov/pubmed/24582860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2014.02.003
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