Complex Actions of Thyroid Hormone Receptor Antagonist NH-3 on Gene Promoters in Different Cell Lines

It is desirable to obtain new antagonists for thyroid hormone (TRs) and other nuclear receptors (NRs). We previously used X-ray structural models of TR ligand binding domains (LBDs) to design compounds, such as NH-3, that impair coactivator binding to activation function 2 (AF-2) and block thyroid h...

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Bibliographic Details
Main Authors: Shah, Vanya, Nguyen, Phuong, Nguyen, Ngoc-Ha, Togashi, Marie, Scanlan, Thomas S., Baxter, John D., Webb, Paul
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180716/
https://ncbi.nlm.nih.gov/pubmed/18930112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2008.09.016
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