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In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells

BACKGROUND: Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodrug esters. Prodrug esters are inactive compounds that can be preferentially act...

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Detalhes bibliográficos
Main Authors: McGoldrick, Christopher A, Jiang, Yu-Lin, Brannon, Marianne, Krishnan, Koyamangalath, Stone, William L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180535/
https://ncbi.nlm.nih.gov/pubmed/25234292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-675
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