In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells

BACKGROUND: Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodrug esters. Prodrug esters are inactive compounds that can be preferentially act...

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Huvudupphovsmän: McGoldrick, Christopher A, Jiang, Yu-Lin, Brannon, Marianne, Krishnan, Koyamangalath, Stone, William L
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180535/
https://ncbi.nlm.nih.gov/pubmed/25234292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-675
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