γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

BACKGROUND: Ceramide synthesis and metabolism is a promising target in cancer drug development. γ-tocotrienol (GT3), a member of the vitamin E family, orchestrates multiple effects that ensure the induction of apoptosis in both, wild-type and RAS-mutated pancreatic cancer cells. Here, we investigate...

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Опубликовано в: :BMC Cancer
Главные авторы: Palau, Victoria E., Chakraborty, Kanishka, Wann, Daniel, Lightner, Janet, Hilton, Keely, Brannon, Marianne, Stone, William, Krishnan, Koyamangalath
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5956825/
https://ncbi.nlm.nih.gov/pubmed/29769046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4462-y
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