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A Novel In Vitro Assay to Assess Phosphorylation of 3′-[(18)F]fluoro-3′-Deoxythymidine
PURPOSE: 3′-[(18)F]fluoro-3’-deoxythymidine ([(18)F]FLT) is phosphorylated by thymidine kinase 1 (TK-1), a cell cycle regulated enzyme. Appropriate use of [(18)F]FLT tracer requires validation of the TK-1 activity. Here, we report development of a novel phosphoryl-transfer assay to assess phosphoryl...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4180216/ https://ncbi.nlm.nih.gov/pubmed/20532643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-010-0351-8 |
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