Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′-deoxythymidine

Anti-HIV nucleoside monophosphates have limited cellular uptake due to the presence of negatively-charged phosphate group. Bis-(cycloSaligenyl) derivatives containing two anti-HIV nucleosides, 3′-fluoro-3′-deoxythymidine (FLT) and 3′-azido-3′-deoxythymidine (AZT) were synthesized to increase intrace...

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Publicado en:Tetrahedron Lett
Main Authors: Ahmadibeni, Yousef, Tiwari, Rakesh, Swepson, Chelsie, Pandhare, Jui, Dash, Chandravanu, Doncel, Gustavo F., Parang, Keykavous
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675361/
https://ncbi.nlm.nih.gov/pubmed/26661937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.12.038
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