Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation

Although the encapsulation of paclitaxel into liposomes has been extensively studied, its significant hydrophobic and uncharged character has generated substantial difficulties concerning its efficient encapsulation into the inner water core of liposomes. We found that a more hydrophilic paclitaxel...

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Autores principales: Shigehiro, Tsukasa, Kasai, Tomonari, Murakami, Masaharu, Sekhar, Sreeja C., Tominaga, Yuki, Okada, Masashi, Kudoh, Takayuki, Mizutani, Akifumi, Murakami, Hiroshi, Salomon, David S., Mikuni, Katsuhiko, Mandai, Tadakatsu, Hamada, Hiroki, Seno, Masaharu
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180071/
https://ncbi.nlm.nih.gov/pubmed/25264848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107976
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