Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation

Although the encapsulation of paclitaxel into liposomes has been extensively studied, its significant hydrophobic and uncharged character has generated substantial difficulties concerning its efficient encapsulation into the inner water core of liposomes. We found that a more hydrophilic paclitaxel...

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Detalhes bibliográficos
Main Authors: Shigehiro, Tsukasa, Kasai, Tomonari, Murakami, Masaharu, Sekhar, Sreeja C., Tominaga, Yuki, Okada, Masashi, Kudoh, Takayuki, Mizutani, Akifumi, Murakami, Hiroshi, Salomon, David S., Mikuni, Katsuhiko, Mandai, Tadakatsu, Hamada, Hiroki, Seno, Masaharu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180071/
https://ncbi.nlm.nih.gov/pubmed/25264848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107976
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