Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation

Although the encapsulation of paclitaxel into liposomes has been extensively studied, its significant hydrophobic and uncharged character has generated substantial difficulties concerning its efficient encapsulation into the inner water core of liposomes. We found that a more hydrophilic paclitaxel...

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Détails bibliographiques
Auteurs principaux: Shigehiro, Tsukasa, Kasai, Tomonari, Murakami, Masaharu, Sekhar, Sreeja C., Tominaga, Yuki, Okada, Masashi, Kudoh, Takayuki, Mizutani, Akifumi, Murakami, Hiroshi, Salomon, David S., Mikuni, Katsuhiko, Mandai, Tadakatsu, Hamada, Hiroki, Seno, Masaharu
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180071/
https://ncbi.nlm.nih.gov/pubmed/25264848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107976
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