Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation

Elevated total cholesterol in midlife has been associated with increased risk of dementia in later life. We have previously shown that low-density lipoprotein (LDL) is more oxidized in the plasma of dementia patients, although total cholesterol levels are not different from those of age-matched cont...

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Detalhes bibliográficos
Main Authors: Dias, Irundika H.K., Mistry, Jayna, Fell, Shaun, Reis, Ana, Spickett, Corinne M., Polidori, Maria C., Lip, Gregory Y.H., Griffiths, Helen R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2014
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Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180009/
https://ncbi.nlm.nih.gov/pubmed/25048970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.07.012
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