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CRE promoter sites modulate alternative splicing via p300-mediated histone acetylation

Histone acetylation modulates alternative splicing of several hundred genes. Here, we tested the role of the histone acetyltransferase p300 in alternative splicing and showed that knockdown of p300 promotes inclusion of the fibronectin (FN1) alternative EDB exon. p300 associates with CRE sites in th...

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Detalhes bibliográficos
Main Authors: Dušková, Eva, Hnilicová, Jarmila, Staněk, David
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179961/
https://ncbi.nlm.nih.gov/pubmed/25019513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.29441
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