Tazarotene Induces Apoptosis in Human Basal Cell Carcinoma via Activation of Caspase-8/t-Bid and the Reactive Oxygen Species-Dependent Mitochondrial Pathway

Previous studies suggest that tazarotene, a new member of the acetylenic class of RARβ/γ selective retinoids which is approved to treat a variety of skin diseases, exhibits an anti-proliferative effect in human basal cell carcinoma (BCC) by triggering caspase-dependent apoptosis. However, the detail...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wu, Chieh-Shan, Chen, Gwo-Shing, Lin, Ping-Yi, Pan, I-Hong, Wang, San-Tang, Lin, Sheng Hao, Yu, Hsin-Su, Lin, Chi-Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2014
Schlagworte:
Original Research ArticlesOrganelles/Autophagy/Apoptosis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179923/
https://ncbi.nlm.nih.gov/pubmed/24927175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2014.2366
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