Dasatinib suppression of medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283

Medulloblastoma (MB) expresses Src kinase, while aurora kinase A overexpression correlates with poor survival. We thus investigated novel combination treatment with dasatinib and AT9283, inhibitors of Src and aurora kinase, respectively, on MB growth in vitro and in vivo. Treatment with each drug si...

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Bibliographische Detailangaben
Hauptverfasser: Petersen, William, Liu, Jingbo, Yuan, Liangping, Zhang, Hongying, Schneiderjan, Matthew, Cho, Yoon-Jae, MacDonald, Tobey J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179499/
https://ncbi.nlm.nih.gov/pubmed/25107642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.07.038
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