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Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure
Sustained forward migration through a fibrillar extracellular matrix requires localization of protrusive signals. Contact with fibronectin at the tip of a cell protrusion activates Rac1, and for linear migration it is necessary to dampen Rac1 activity in off-axial positions and redistribute Rac1 fro...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Company of Biologists
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4179493/ https://ncbi.nlm.nih.gov/pubmed/25074804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.154864 |
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