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Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure
Sustained forward migration through a fibrillar extracellular matrix requires localization of protrusive signals. Contact with fibronectin at the tip of a cell protrusion activates Rac1, and for linear migration it is necessary to dampen Rac1 activity in off-axial positions and redistribute Rac1 fro...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Company of Biologists
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4179493/ https://ncbi.nlm.nih.gov/pubmed/25074804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.154864 |
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