Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure

Sustained forward migration through a fibrillar extracellular matrix requires localization of protrusive signals. Contact with fibronectin at the tip of a cell protrusion activates Rac1, and for linear migration it is necessary to dampen Rac1 activity in off-axial positions and redistribute Rac1 fro...

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Autors principals: Williamson, Rosalind C., Cowell, Christopher A. M., Hammond, Christina L., Bergen, Dylan J. M., Roper, James A., Feng, Yi, Rendall, Thomas C. S., Race, Paul R., Bass, Mark D.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179493/
https://ncbi.nlm.nih.gov/pubmed/25074804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.154864
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