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Structure–activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects
The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a member of the ATP-binding cassette transporter superfamily that functions as an epithelial chloride channel. Gating of the CFTR ion conduction pore involves a conserved irreversible cyclic mechanism driven by ATP binding and hy...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4178936/ https://ncbi.nlm.nih.gov/pubmed/25267914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411246 |
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