Hypertriglyceridemia associated with the c.553G>T APOA5 SNP results from aberrant hetero-disulfide bond formation

OBJECTIVE: Apolipoprotein (apo) A-V is a low abundance plasma protein that modulates triacylglycerol (TG) homeostasis. Gene transfer studies were undertaken in apoa5 (−/−) mice to define the mechanism underlying the correlation between the single nucleotide polymorphism (SNP) c.553G>T in APOA5 an...

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Hoofdauteurs: Sharma, Vineeta, Witkowski, Andrzej, Witkowska, H. Ewa, Dykstra, Andrew, Simonsen, Jens B., Nelbach, Lisa, Beckstead, Jennifer A., Pullinger, Clive R., Kane, John P., Malloy, Mary J., Watson, Gordon, Forte, Trudy M., Ryan, Robert O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178935/
https://ncbi.nlm.nih.gov/pubmed/25127531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.304027
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