Broadly Neutralizing Antibody VRC01 Prevents HIV-1 Transmission from Plasmacytoid Dendritic Cells to CD4 T Lymphocytes

Plasmacytoid dendritic cells (pDC) poorly replicate human immunodeficiency virus type 1 (HIV-1) but efficiently transfer HIV-1 to adjacent CD4 T lymphocytes. We found that coculture with T lymphocytes downregulates SAMHD1 expression, enhances HIV-1 replication, and increases pDC maturation and alpha...

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Bibliographic Details
Main Authors: Su, Bin, Lederle, Alexandre, Laumond, Géraldine, Ducloy, Camille, Schmidt, Sylvie, Decoville, Thomas, Moog, Christiane
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178849/
https://ncbi.nlm.nih.gov/pubmed/24965460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01748-14
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