Dendritic Cell-Lymphocyte Cross Talk Downregulates Host Restriction Factor SAMHD1 and Stimulates HIV-1 Replication in Dendritic Cells

Human immunodeficiency virus type 1 (HIV-1) replication in dendritic cells (DCs) is restricted by SAMHD1. This factor is counteracted by the viral protein Vpx; Vpx is found in HIV-2 and simian immunodeficiency virus (SIV) from sooty mangabeys (SIVsm) or from macaques (SIVmac) but is absent from HIV-...

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Main Authors: Su, Bin, Biedma, Marina Elizabeth, Lederle, Alexandre, Peressin, Maryse, Lambotin, Mélanie, Proust, Alizé, Decoville, Thomas, Schmidt, Sylvie, Laumond, Géraldine, Moog, Christiane
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993804/
https://ncbi.nlm.nih.gov/pubmed/24574390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03057-13
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