Phosphodiesterase 1A Modulates Cystogenesis in Zebrafish

Substantial evidence indicates the importance of elevated cAMP in polycystic kidney disease (PKD). Accumulation of cAMP in cystic tissues may be, in part, caused by enhanced adenylyl cyclase activity, but inhibition of cAMP degradation by phosphodiesterases (PDE) likely has an important role, becaus...

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Bibliografiset tiedot
Päätekijät: Sussman, Caroline R., Ward, Christopher J., Leightner, Amanda C., Smith, Jordan L., Agarwal, Reema, Harris, Peter C., Torres, Vicente E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Nephrology 2014
Aiheet:
Basic Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178429/
https://ncbi.nlm.nih.gov/pubmed/24700876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013040421
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