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Single-molecule real-time detection of telomerase extension activity
The ends of eukaryotic chromosomes are capped by telomeres which consist of tandem G-rich DNA repeats stabilized by the shelterin protein complex. Telomeres shorten progressively in most normal cells due to the end replication problem. In more than 85% of cancers however, the telomere length is main...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4178293/ https://ncbi.nlm.nih.gov/pubmed/25263700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06391 |
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