Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

BACKGROUND: Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnormalities which are contributing factors to breast tumor progression. Genomic ma...

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Detalhes bibliográficos
Main Authors: Luo, Yongde, Yang, Chaofeng, Ye, Min, Jin, Chengliu, Abbruzzese, James L, Lee, Mong-Hong, Yeung, Sai-Ching J, McKeehan, Wallace L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178208/
https://ncbi.nlm.nih.gov/pubmed/24279986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-21
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