Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

BACKGROUND: Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnormalities which are contributing factors to breast tumor progression. Genomic ma...

Full description

Saved in:
Bibliographic Details
Main Authors: Luo, Yongde, Yang, Chaofeng, Ye, Min, Jin, Chengliu, Abbruzzese, James L, Lee, Mong-Hong, Yeung, Sai-Ching J, McKeehan, Wallace L
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178208/
https://ncbi.nlm.nih.gov/pubmed/24279986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-21
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items