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IGF-IR Mediated Mammary Tumorigenesis Is Enhanced during Pubertal Development

Although breast cancer typically develops in women over the age of 40, it remains unclear when breast cancer initiating events occur or whether the mammary gland is particularly susceptible to oncogenic transformation at a particular developmental stage. Using MTB-IGFIR transgenic mice that overexpr...

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Détails bibliographiques
Auteurs principaux: Jones, Robert A., Watson, Katrina L., Campbell, Craig I., Moorehead, Roger A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178186/
https://ncbi.nlm.nih.gov/pubmed/25259518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108781
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