A New IRAK-M-Mediated Mechanism Implicated in the Anti-Inflammatory Effect of Nicotine via α7 Nicotinic Receptors in Human Macrophages

Nicotine stimulation of α7 nicotinic acetylcholine receptor (α7 nAChR) powerfully inhibits pro-inflammatory cytokine production in lipopolysaccharide (LPS)-stimulated macrophages and in experimental models of endotoxemia. A signaling pathway downstream from the α7 nAChRs, which involves the collabor...

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Main Authors: Maldifassi, Maria C., Atienza, Gema, Arnalich, Francisco, López-Collazo, Eduardo, Cedillo, Jose L., Martín-Sánchez, Carolina, Bordas, Anna, Renart, Jaime, Montiel, Carmen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178160/
https://ncbi.nlm.nih.gov/pubmed/25259522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108397
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