The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release

Gene duplication generates new functions and traits, enabling evolution. Human-specific duplicated genes in particular are primary sources of innovation during our evolution although they have very few known functions. Here we examine the brain function of one of these genes (CHRFAM7A) and its produ...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Martín-Sánchez, Carolina, Alés, Eva, Balseiro-Gómez, Santiago, Atienza, Gema, Arnalich, Francisco, Bordas, Anna, Cedillo, José L., Extremera, María, Chávez-Reyes, Arturo, Montiel, Carmen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949125/
https://ncbi.nlm.nih.gov/pubmed/33515545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100341
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