The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release

Gene duplication generates new functions and traits, enabling evolution. Human-specific duplicated genes in particular are primary sources of innovation during our evolution although they have very few known functions. Here we examine the brain function of one of these genes (CHRFAM7A) and its produ...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Martín-Sánchez, Carolina, Alés, Eva, Balseiro-Gómez, Santiago, Atienza, Gema, Arnalich, Francisco, Bordas, Anna, Cedillo, José L., Extremera, María, Chávez-Reyes, Arturo, Montiel, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949125/
https://ncbi.nlm.nih.gov/pubmed/33515545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100341
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