Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema

BACKGROUND: In this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an inherited deficiency of connective tissue might play a role in the combined development of pulmonary em...

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Main Authors: Ramnath, Natasja W. M., van de Luijtgaarden, Koen M., van der Pluijm, Ingrid, van Nimwegen, Menno, van Heijningen, Paula M., Swagemakers, Sigrid M. A., van Thiel, Bibi S., Ridwan, Ruziedi Y., van Vliet, Nicole, Vermeij, Marcel, Hawinkels, Luuk J. A. C., de Munck, Anne, Dzyubachyk, Oleh, Meijering, Erik, van der Spek, Peter, Rottier, Robbert, Yanagisawa, Hiromi, Hendriks, Rudi W., Kanaar, Roland, Rouwet, Ellen V., Kleinjan, Alex, Essers, Jeroen
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177830/
https://ncbi.nlm.nih.gov/pubmed/25255451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106054
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