Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema

BACKGROUND: In this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an inherited deficiency of connective tissue might play a role in the combined development of pulmonary em...

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Detalhes bibliográficos
Main Authors: Ramnath, Natasja W. M., van de Luijtgaarden, Koen M., van der Pluijm, Ingrid, van Nimwegen, Menno, van Heijningen, Paula M., Swagemakers, Sigrid M. A., van Thiel, Bibi S., Ridwan, Ruziedi Y., van Vliet, Nicole, Vermeij, Marcel, Hawinkels, Luuk J. A. C., de Munck, Anne, Dzyubachyk, Oleh, Meijering, Erik, van der Spek, Peter, Rottier, Robbert, Yanagisawa, Hiromi, Hendriks, Rudi W., Kanaar, Roland, Rouwet, Ellen V., Kleinjan, Alex, Essers, Jeroen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177830/
https://ncbi.nlm.nih.gov/pubmed/25255451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106054
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