Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels

Fibulins are extracellular matrix proteins associated with elastic fibres. Homozygous Fibulin-4 mutations lead to life-threatening abnormalities such as aortic aneurysms. Aortic aneurysms in Fibulin-4 mutant mice were associated with upregulation of TGF-β signalling. How Fibulin-4 deficiency leads t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Ramnath, N. W. M., Hawinkels, L. J. A. C., van Heijningen, P. M., Riet, L. te, Paauwe, M., Vermeij, M., Danser, A. H. J., Kanaar, R., ten Dijke, P., Essers, J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660353/
https://ncbi.nlm.nih.gov/pubmed/26607280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16872
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