Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1

Neuregulin 1 (Nrg1) is a susceptibility gene of schizophrenia, a disabling mental illness that affects 1% of the general population. Here we show that ctoNrg1 mice, which mimic high levels of NRG1 observed in forebrain regions of schizophrenic patients, exhibit behavioral deficits and hypofunction o...

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Main Authors: Yin, Dong-Min, Chen, Yong-Jun, Lu, Yi-Sheng, Bean, Jonathan C, Sathyamurthy, Anupama, Shen, Chengyong, Liu, Xihui, Smith, Clifford, Xiong, Wen-Cheng, Mei, Lin
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176764/
https://ncbi.nlm.nih.gov/pubmed/23719163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.03.028
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