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Differential triggering of spontaneous glutamate release by P/Q-, N-, and R-type Ca(2+) channels

The role of voltage-gated Ca(2+) channels (VGCCs) in spontaneous miniature neurotransmitter release is incompletely understood. Here we show that stochastic opening of P/Q-, N-, and R-type VGCCs accounts for ~50% of all spontaneous glutamate release at rat cultured hippocampal synapses, and that R-t...

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Detalhes bibliográficos
Main Authors: Ermolyuk, Yaroslav S., Alder, Felicity G., Surges, Rainer, Pavlov, Ivan Y., Timofeeva, Yulia, Kullmann, Dimitri M., Volynski, Kirill E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176737/
https://ncbi.nlm.nih.gov/pubmed/24185424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3563
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