Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer

BACKGROUND: KRAS mutations in codons 12 and 13 are present in ∼40% of all colorectal cancers (CRC). Activating mutations in codons 61 and 146 of KRAS and in codons 12, 13, and 61 of NRAS also occur but are less frequent. The clinicopathologic features and gene expression profiles of this latter subp...

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Detalhes bibliográficos
Main Authors: Morris, V. K., Lucas, F. A. San, Overman, M. J., Eng, C., Morelli, M. P., Jiang, Z.-Q., Luthra, R., Meric-Bernstam, F., Maru, D., Scheet, P., Kopetz, S., Vilar, E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176451/
https://ncbi.nlm.nih.gov/pubmed/25009008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdu252
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