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Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability
R-loops, transcriptionally-induced RNA:DNA hybrids, occurring at repeat tracts (CTG)(n), (CAG)(n), (CGG)(n), (CCG)(n) and (GAA)(n), are associated with diseases including myotonic dystrophy, Huntington's disease, fragile X and Friedreich's ataxia. Many of these repeats are bidirectionally...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176329/ https://ncbi.nlm.nih.gov/pubmed/25147206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku658 |
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