TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)n Repeat of the C9orf72 Gene and Blocks Interaction of RNA-binding Proteins

Certain DNA and RNA sequences can form G-quadruplexes, which can affect genetic instability, promoter activity, RNA splicing, RNA stability, and neurite mRNA localization. Amyotrophic lateral sclerosis and frontotemporal dementia can be caused by expansion of a (GGGGCC)n repeat in the C9orf72 gene....

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Main Authors: Zamiri, Bita, Reddy, Kaalak, Macgregor, Robert B., Pearson, Christopher E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931028/
https://ncbi.nlm.nih.gov/pubmed/24371143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.502336
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