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Autoinhibition of Bacteriophage T4 Mre11 by Its C-terminal Domain

Mre11 and Rad50 form a stable complex (MR) and work cooperatively in repairing DNA double strand breaks. In the bacteriophage T4, Rad50 (gene product 46) enhances the nuclease activity of Mre11 (gene product 47), and Mre11 and DNA in combination stimulate the ATPase activity of Rad50. The structural...

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Bibliografiska uppgifter
Huvudupphovsmän: Gao, Yang, Nelson, Scott W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176212/
https://ncbi.nlm.nih.gov/pubmed/25077970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.583625
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