Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection

BLM, a RecQ family DNA helicase mutated in Bloom's Syndrome, participates in homologous recombination at two stages: 5′ DNA end resection and double Holliday junction dissolution. BLM exists in a complex with Topo IIIα, RMI1 and RMI2. Herein, we address the role of Topo IIIα and RMI1-RMI2 in re...

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Bibliografische gegevens
Hoofdauteurs: Daley, James M., Chiba, Tamara, Xue, Xiaoyu, Niu, Hengyao, Sung, Patrick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176181/
https://ncbi.nlm.nih.gov/pubmed/25200081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku803
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